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Research Frontiers
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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxadiol (PPD)


 

Classification of ginsenosides

The dripping pill (micropellet) preparation of dammarane sapogenins PPD & PPT
Dammarane sapogenins (protopanaxadiol / PPD and protopanaxatriol / PPT) are well recognized for their therapeutical efficacy in cancers and other chronic health conditions. However, PPD and PPT are highly hydrophobic (in other words, they are lipophi...
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Ginsenosides are main active ingredients in Asian ginseng and American ginseng.

To date, more than 40 ginsenosides are found. Ginsenosides are denoted by -RX (note: X=0、a1、a2、a3、b1、b2、b3、c、d、e、f、g1、g2、g3、h1、h2、h3、s1、s2). In addition, F11 belongs to pseudoginsenoside saponin.

According to their mother ring structure, ginsenosides can be classified into 3 types:

  • oleanolic acid type
  • dammarane type
  • Ocotillol type

Dammarane type saponins account for 70% of total saponins in ginseng, and it can be further categorized into protopanaxadiol-type and protopanaxatriol-type, their mother ring structures are listed below.

PPD

PPT

Chemical processing or hydrolysis in GI tract will convert above two types of ginsenosides into aglycone protopanaxadiol (PPD) and protopanaxatriol (PPT).

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